Spontaneous resolution of advanced basal cell carcinoma after short-pulse treatment with hedgehog pathway inhibitor

BCC: basal cell carcinoma HPI: hedgehog pathway inhibitors laBCC: locally advanced basal cell carcinoma RT: radiotherapy INTRODUCTION Hedgehog pathway inhibitors (HPIs) are indicated for locally advanced basal cell carcinoma (laBCC) and metastatic basal cell carcinoma with reported treatment length of 5.5months tomore than 5 years. The definition of laBCC is historically ill described and only recently has a consensus definition been proposed. Treatment is indicated until tumor resistance or adverse events cause interruption. Therefore, we do not know the length of treatment necessary for tumor clearance. We describe a patient who received a single 2-week pulse treatment of HPI therapy and subsequently experienced sustained clinical and histologic clearance of his tumor.